Polynucleotides in Skincare – The Future Key to Youthful Skin

Modern aesthetic medicine has moved beyond surface-level skincare to scientifically advanced treatments that work on a cellular level. One of the most promising and effective innovations in this field is polynucleotides – compounds that activate the skin’s natural regeneration and rejuvenation processes.

What are polynucleotides?

Polynucleotides are biotechnological molecules derived from purified salmon DNA. They contain no genes and do not affect your own DNA or hormones. Their purpose is to provide the skin with essential building blocks and to trigger its natural repair mechanisms.

They are completely biocompatible and safe for the human body. Polynucleotides have powerful regenerative, hydrating, and antioxidant properties, helping the skin to:

• Recover from damage
• Stimulate collagen and elastin production
• Retain moisture deep within the skin
• Reduce inflammation, redness, and irritation
• Protect against free radicals and premature aging

Their effect can be compared to activating the skin’s own “self-renewal system” – particularly beneficial for aging skin, facial laxity, sun damage, and dehydration. The result is firmer, plumper, more hydrated, and radiant skin, with improvements that build up and last over time.

Who are polynucleotide treatments for?

Polynucleotide therapy is an excellent choice when:

• You start noticing the first signs of aging – such as sagging, fine lines, or dullness
• Your skin feels dry, thin, or tired after sun exposure or aggressive treatments
• You struggle with uneven skin tone or enlarged pores
• You want to firm the skin of the face, neck, décolletage, or hands, especially in areas that need structural repair and renewal
• You want visible, long-lasting results without aggressive procedures

Polynucleotides are also suitable for younger skin (from the age of 25), especially when there are signs of premature aging caused by stress, lack of sleep, or dehydration, as well as acne marks, scars, or enlarged pores. They are also an excellent choice for preparing the skin before sun exposure or helping it recover afterward.

Polynucleotides work preventively – not just as a “rescue” solution for existing concerns.

When is the treatment not recommended?

Polynucleotide treatment is not recommended if the treated area has an active inflammation or infection (such as herpes or acne), if you are taking anticoagulant medication, have cancer, a blood clotting disorder, or are pregnant or breastfeeding.

TWAC 3.0 – The Next Generation of Polynucleotide Therapy

TWAC 3.0 combines 20 mg/ml of polynucleotides with 20 mg/ml of high-molecular-weight hyaluronic acid, delivering an advanced and multi-active skin rejuvenation treatment.

Benefits of TWAC 3.0 treatment:

• Rejuvenating effect: activates fibroblasts and stimulates collagen production.
• Skin firming: significantly improves skin texture, elasticity, and tone.
• Deep hydration: provides long-lasting moisture thanks to hyaluronic acid.
• Suitable for all skin types: including sensitive and mature skin.

TWAC 3.0 is an excellent choice if you have:

• Early signs of aging (25+)
• Decreased skin elasticity or sagging
• Couperose, inflammation, or sun damage
• Skin recovering from laser, peeling, or other procedures
• Dull, tired, or stressed skin

Why is TWAC 3.0 special?

• High PDRN concentration effectively stimulates cellular regeneration.
• Rich hyaluronic acid content deeply hydrates and supports tissue structure.
• No lidocaine – reduced risk of allergies and irritation.
• Pure, physiological formula: free from fragrances, dyes, and preservatives.
• At our clinic, we use only original TWAC 3.0 – a safe, clinically tested product with proven therapeutic quality.

Results of TWAC 3.0 treatment:

After just one session:

• Skin feels firmer and more hydrated
• Tired skin appears brighter and more refreshed
• Skin tone and radiance improve
• Fine lines become visibly smoother

After just 2–3 sessions:

• Acne marks and pigmentation fade
• Skin texture and surface become smoother
• Visible redness and couperose significantly decrease
• Long-term neocollagenesis begins – the skin starts to regenerate naturally

Can TWAC 3.0 be combined with other treatments?

Yes – and doing so often enhances the results even further:

• Compatible with EXION RF Microneedling microneedling, Clear RF micro-ablation, laser resurfacing, chemical peels, thread lifts, and IPL treatments.
• Can be combined with other biostimulators, mesotherapy, and professional skincare treatments.
• Before fillers, TWAC strengthens and prepares the skin, resulting in longer-lasting and more natural outcomes.
• After aggressive treatments, TWAC accelerates skin regeneration and reduces the risk of pigmentation or scarring.
• In some cases, it can also be used on the body – such as the abdomen, knees, and inner arms – to restore and firm the skin.
• Ideal for pre-sun preparation, as polynucleotides provide both protective and reparative effects against sun-induced damage.

Treatment Experience and Recovery

• The procedure takes about 20–40 minutes and is painless thanks to the use of a local anesthetic.
• In more sensitive areas, you may feel only a slight tingling sensation.
• Immediately after the treatment, the skin feels firmer and more hydrated.
• Mild swelling, small bumps, or minor bruising may occur but typically subside within a few days.

How often should the treatment be done, and how long do the results last?

A full course usually consists of 2–4 sessions, spaced about four weeks apart. The effects build progressively and can last up to 6–9 months.

TWAC Eyes – Gentle Care for the Delicate Eye Area

The skin around the eyes requires special attention – it’s thinner, loses moisture faster, and is the first to reveal signs of fatigue and aging.

TWAC Eyes is specifically designed for this area, taking into account its unique anatomical and physiological characteristics.

Active ingredients

Polynucleotides (PDRN) 2 mg/ml – promote cellular regeneration and improve microcirculation, enhancing skin elasticity.

The lightweight, well-tolerated formula makes the treatment comfortable and safe.

Benefits of TWAC Eyes treatment:

• Reduces puffiness and dark circles
• Strengthens blood vessels and improves microcirculation
• Smooths fine lines and crow’s feet
• Deeply hydrates without causing swelling, thanks to the optimal hyaluronic acid concentration

Treatment plan:

A course of 3–4 sessions spaced two weeks apart. Maintenance: 1 session every 3–4 months. First results are visible immediately and continue to improve with each session.

Contraindications: same as with other injectable treatments (antibiotic therapy, flare-up of chronic diseases, autoimmune conditions).